Dimethylamine → HCID 86670207, compound

HRID 2046242Notes

Reaction equation

HRID 2046242 reaction equation
[Br:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4](F)[N:3]=1.CO.[CH3:12][NH:13][CH3:14]>[Cl-].[Na+].O>[Br:1][C:2]1[N:3]=[C:4]([N:13]([CH3:14])[CH3:12])[CH:5]=[CH:6][C:7]=1[F:8]

Participants

5

Reactant 3

HCID 674DimethylamineHCID 887MethanolHCID 729425092-BroMo-3,6-difluoropyridine

Product 1

HCID 86670207HCID 86670207, compound

Reagents, catalysts & solvents 1

HCID 57417360Sodium chloride; waterSolvent

Conditions

Temperature
80 °C

Procedure

2-Bromo-3,6-difluoro-pyridine (300 mg, 1.5 mmol) was dissolved in a 2M solution of dimethylamine in MeOH (7.8 mL, 15.56 mmol) and stirred at 80° C. in a sealed tube for 16 hours. The mixture was treated with brine and extracted with DCM. The organic layer was separated, dried (MgSO4), filtered and the solvents evaporated in vacuo to yield (6-bromo-5-fluoro-pyridin-2-yl)-dimethyl-amine as a dark oil that was used in the next step without further purification.

Workup

  1. extractionextracted with DCM
  2. customThe organic layer was separated
  3. dry with materialdried (MgSO4)
  4. filtrationfiltered
  5. customthe solvents evaporated in vacuo

Sources & evidence

ORD record
ord-59290d44800740109ac9fedd17cd7aa8
Source dataset
uspto-grants-2013_11
Patent number
US08592422B2

Reaction notes

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