1-benzyl-N-methylpiperidin-4-amine → Tert-butyl 2-(1-((1-benzylpiperidine-4-yl)(methyl)amino)-1-oxopropane-2-yloxy)-4,6-dimethylpyrimidine-5-ylcarbamate

HRID 2046347Notes

Reaction equation

HRID 2046347 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1[C:10]([CH3:22])=[N:11][C:12]([O:16][CH:17]([CH3:21])[C:18]([OH:20])=O)=[N:13][C:14]=1[CH3:15])=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:23]([N:30]1[CH2:35][CH2:34][CH:33]([NH:36][CH3:37])[CH2:32][CH2:31]1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH2:23]([N:30]1[CH2:35][CH2:34][CH:33]([N:36]([CH3:37])[C:18](=[O:20])[CH:17]([O:16][C:12]2[N:13]=[C:14]([CH3:15])[C:9]([NH:8][C:6](=[O:7])[O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[C:10]([CH3:22])[N:11]=2)[CH3:21])[CH2:32][CH2:31]1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 41361281-benzyl-N-methylpiperidin-4-amineHCID 593360932-(5-(Tert-butoxycarbonylamino)-4,6-dimethylpyrimidine-2-yloxy)propanoic acid

Product 1

HCID 59336090Tert-butyl 2-(1-((1-benzylpiperidine-4-yl)(methyl)amino)-1-oxopropane-2-yloxy)-4,6-dimethylpyrimidine-5-ylcarbamate

Procedure

The title compound was synthesized from Compound 12 and 1-benzyl-N-methylpiperidine-4-amine in the same manner as in Example 49.

Sources & evidence

ORD record
ord-b554f49870044a32aab036c1d8fed134
Source dataset
uspto-grants-2013_11
Patent number
US08592435B2

Reaction notes

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