Water → HCID 58046439, compound

Participants

Reaction Conditions

Reaction Steps

2,2-Dibromo-1-(imidazo[1,2-b]pyridazin-3-yl)ethanone (790 mg, 2.48 mmol) and ethyl thiooxamate (547 mg, 3.96 mmol) were dissolved in 1,4-dioxane (24.8 mL) and heated to 100° C. for 4 h. The solution was cooled to room temperature and water was added. The aqueous layer was extracted with ethyl acetate (×3). The organic layers were combined and dried with magnesium sulfate, filtered, and concentrated under reduced pressure to give the title compound as an orange solid. 1H NMR (500 MHz, CD3SOCD3) δ 8.79 (s, 1H); 8.77 (d, 1H); 8.33 (s, 1H); 8.30 (d, 1H); 7.39 (dd, 1H); 4.43 (q, 2H); 1.36 (t, 3H). LRMS (APCI) calc'd for (C12H10N4O2S) [M+H]+, 275.1. found 275.0.

Provenance & Evidence