5-(4-Chlorophenyl)-2-[(dimethylamino)methylene]-1,3-cyclohexanedione → 2-[(Dimethylamino)methylene]-5-(4-fluorophenyl)-1,3-cyclohexanedione
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][C:12](=[O:14])[CH2:11][C:10](=[O:15])[CH2:9]2)=[CH:4][CH:3]=1.ClC1C=CC(C2CC(=O)C(=[CH:30][N:31]([CH3:33])[CH3:32])C(=O)C2)=CC=1>>[CH3:30][N:31]([CH:33]=[C:11]1[C:12](=[O:14])[CH2:13][CH:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[CH2:9][C:10]1=[O:15])[CH3:32]Participants
3
Procedure
The title compound was prepared from 5-(4-fluoro-phenyl)cyclohexane-1,3-dione (1.0 g, 4.85 mmol), following the procedure described for 5-(4-chloro-phenyl)-2-dimethylaminomethylene-cyclohexane-1,3-dione (example 2/a stage 1) except that the reaction was run at ambient temperature for 10 min.
Sources & evidence
- ORD record
- ord-38524baad45f47499ab2b343303536cc
- Source dataset
- uspto-grants-2013_11
- Patent number
- US08592430B2
Reaction notes
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