HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine Hydrochloride → 2-amino-7-(2-thienyl)-7,8-dihydroquinazolin-5(6H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine Hydrochloride | HCID 5742 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-amino-7-(4-chlorophenyl)-7,8-dihydroquinazolin-5(6H)-one | HCID 2772371 | — |
| Reactant | 2-[(Dimethylamino)methylidene]-5-(thiophen-2-yl)cyclohexane-1,3-dione | HCID 30033378 | — |
| Product | 2-amino-7-(2-thienyl)-7,8-dihydroquinazolin-5(6H)-one | HCID 3834182 | — |
Reaction Steps
The title compound was prepared from 2-dimethylaminomethylene-5-thien-2-yl-cyclohexane-1,3-dione (267 mg, 1.09 mmol) from stage 1, guanidine hydrochloride (205 mg, 2.14 mmol) and sodium carbonate (342 mg, 3.21 mmol), following the procedure described for the synthesis of 2-amino-7-(4-chloro-phenyl)-7,8-dihydro-6H-quinazolin-5-one (example 2/a stage 2) except that the mixture was heated to reflux for 16 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592430B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-fb78a94eab7e424ab47e612ad09fcc48 |
| Source note | uspto-grants-2013_11 |