HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine Hydrochloride → 2-Amino-7-(2-fluoro-phenyl)-7,8-dihydro-6H-quinazolin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine Hydrochloride | HCID 5742 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-amino-7-(4-chlorophenyl)-7,8-dihydroquinazolin-5(6H)-one | HCID 2772371 | — |
| Reactant | 2-Dimethylaminomethylene-5-(2-fluoro-phenyl)-cyclohexane-1,3-dione | HCID 58269402 | — |
| Product | 2-Amino-7-(2-fluoro-phenyl)-7,8-dihydro-6H-quinazolin-5-one | HCID 58269394 | — |
Reaction Steps
The title compound was prepared from 2-dimethylaminomethylene-5-(2-fluoro-phenyl)-cyclohexane-1,3-dione (919 mg, 3.53 mmol) from stage 1, guanidine hydrochloride (673 mg, 7.04 mmol) and sodium carbonate (1.12 g, 10.59 mmol), following the procedure described for the synthesis of 2-amino-7-(4-chloro-phenyl)-7,8-dihydro-6H-quinazolin-5-one (example 2/a stage 2) except that the mixture was heated at reflux for 16 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592430B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-00677db790b64cf79fd4c8573cfe9a13 |
| Source note | uspto-grants-2013_11 |