Sodium Acetate → 2-Acetyl-5-(furan-2-yl)cyclohexane-1,3-dione

HRID 2046468Notes

Reaction equation

[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[CH2:11][C:10](=[O:12])[CH2:9][C:8](=[O:13])[CH2:7]1.[C:14]([O-])(=[O:16])[CH3:15].[Na+].C(C1C(=O)CC(C2C=CC(F)=CC=2)CC1=O)(=O)C>>[C:14]([CH:9]1[C:10](=[O:12])[CH2:11][CH:6]([C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)[CH2:7][C:8]1=[O:13])(=[O:16])[CH3:15]

Participants

Reactant 3

HCID 517045Sodium Acetate

HCID 6995135-(2-Furyl)cyclohexane-1,3-dione

HCID 529508832-Acetyl-5-(4-fluoro-phenyl)cyclohexane-1,3-dione

Product 1

HCID 53059482-Acetyl-5-(furan-2-yl)cyclohexane-1,3-dione

Procedure

The title compound was prepared from 5-(2-furyl)-cyclohexane-1,3-dione (500 mg, 2.8 mmol) and sodium acetate (229 mg, 2.8 mmol), following the procedure describing the synthesis of 2-acetyl-5-(4-fluoro-phenyl)-cyclohexane-1,3-dione (example 3/a stage 1).

Sources & evidence

ORD record: ord-30d712abbdf645c699e3c8363218d0b5
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592430B2

Reaction notes

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