2-Amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oxime → 2-Amino-7-furan-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oxime

HRID 2046470Notes

Reaction equation

HRID 2046470 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([CH3:12])[C:9]2[C:8](=[N:13][OH:14])[CH2:7][CH:6]([C:15]3[O:16][CH:17]=[CH:18][CH:19]=3)[CH2:5][C:4]=2[N:3]=1.[CH3:20][N:21]([CH3:45])[CH2:22][CH2:23]ON=C1CC(C2C=CC(F)=CC=2)CC2N=C(N)N=C(C)C1=2>>[CH3:20][N:21]([CH3:45])[CH2:22][CH2:23][O:14][N:13]=[C:8]1[CH2:7][CH:6]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)[CH2:5][C:4]2[N:3]=[C:2]([NH2:1])[N:11]=[C:10]([CH3:12])[C:9]1=2

Participants

3

Reactant 2

HCID 866535522-Amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oximeHCID 866535542-amino-7-furan-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime2×

Product 1

HCID 767509332-Amino-7-furan-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oxime

Procedure

The title compound was prepared from 2-amino-7-furan-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime (compound 33), following the procedure describing the synthesis of 2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one O-(2-dimethylamino-ethyl)-oxime (example 3/a stage 5).

Sources & evidence

ORD record
ord-cf21003eb02e4990b2eba019ff434e59
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

Loading…