Sodium Acetate → 2-Acetyl-5-thien-2-yl-cyclohexane-1,3-dione

HRID 2046471Notes

Reaction equation

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]1[CH2:11][C:10](=[O:12])[CH2:9][C:8](=[O:13])[CH2:7]1.[C:14]([O-])(=[O:16])[CH3:15].[Na+].C(C1C(=O)CC(C2C=CC(F)=CC=2)CC1=O)(=O)C>>[C:14]([CH:9]1[C:10](=[O:12])[CH2:11][CH:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)[CH2:7][C:8]1=[O:13])(=[O:16])[CH3:15]

Participants

Reactant 3

HCID 517045Sodium Acetate

HCID 5736855-(2-Thienyl)cyclohexane-1,3-dione

HCID 529508832-Acetyl-5-(4-fluoro-phenyl)cyclohexane-1,3-dione

Product 1

HCID 529502492-Acetyl-5-thien-2-yl-cyclohexane-1,3-dione

Procedure

The title compound was prepared from 5-thien-2-yl-cyclohexane-1,3-dione (600 mg, 3.09 mmol) and sodium acetate (253 mg, 3.09 mmol), following the procedure describing the synthesis of 2-acetyl-5-(4-fluoro-phenyl)-cyclohexane-1,3-dione (example 3/a stage 1).

Sources & evidence

ORD record: ord-430fb5fa4fed483ebf4b6209f1a9ae94
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592430B2

Reaction notes

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