2-Amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one → 2-Amino-4-methyl-7-p-tolyl-7,8-dihydro-6H-quinazolin-5-one

HRID 2046474Notes

Reaction equation

HRID 2046474 reaction equation
[C:1]([CH:4]1[C:9](=[O:10])[CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)[CH2:6][C:5]1=O)(=O)[CH3:2].[NH2:19][C:20]1[N:29]=C(C)C2C(=O)CC(C3C=CC(F)=CC=3)CC=2[N:21]=1>>[NH2:29][C:20]1[N:21]=[C:1]([CH3:2])[C:4]2[C:9](=[O:10])[CH2:8][CH:7]([C:11]3[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=3)[CH2:6][C:5]=2[N:19]=1

Participants

3

Reactant 2

HCID 172212082-Amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-oneHCID 582694112-Acetyl-5-p-tolyl-cyclohexane-1,3-dione

Product 1

HCID 172211972-Amino-4-methyl-7-p-tolyl-7,8-dihydro-6H-quinazolin-5-one

Procedure

The title compound was prepared from 2-acetyl-5-p-tolyl-cyclohexane-1,3-dione (850 mg, 3.50 mmol), stage 1, following the procedure describing the synthesis of 2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one (example 3/a stage 2/3).

Sources & evidence

ORD record
ord-f631d4e1c9cc4488a72cb17188c86f3b
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

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