Pyridine-2-boronic acid → HCID 58269386, compound

HRID 2046485Notes

Reaction equation

HRID 2046485 reaction equation
[NH2:1][C:2]1[N:11]=[CH:10][C:9]2[C:8](=[O:12])[CH2:7][CH:6]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3Br)[CH2:5][C:4]=2[N:3]=1.NC1N=CC2C(=O)CC(C3C=CC(F)=CC=3[C:39]3[CH:40]=[N:41][CH:42]=[CH:43][CH:44]=3)CC=2N=1.N1C=CC=CC=1B(O)O>>[NH2:1][C:2]1[N:11]=[CH:10][C:9]2[C:8](=[O:12])[CH2:7][CH:6]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:40]3[CH:39]=[CH:44][CH:43]=[CH:42][N:41]=3)[CH2:5][C:4]=2[N:3]=1

Participants

4

Reactant 3

HCID 2762745Pyridine-2-boronic acidHCID 58269374HCID 58269374, compoundHCID 58269407HCID 58269407, compound

Product 1

HCID 58269386HCID 58269386, compound

Procedure

The title compound was prepared from 2-amino-7-(2-bromo-phenyl)-7,8-dihydro-6H-quinazolin-5-one (example 2/h stage 2), following the procedure describing the synthesis of 2-amino-7-(4-fluoro-2-pyridin-3-yl-phenyl)-7,8-dihydro-6H-quinazolin-5-one (example 4/a stage 1) using 2-pyridyl boronic acid instead of 3-pyridyl boronic acid.

Sources & evidence

ORD record
ord-8e9dc622f8934b8bb46cd853be2bc9d5
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

Loading…