HCID 58269374, compound → HCID 67159084, compound

HRID 2046490Notes

Reaction equation

HRID 2046490 reaction equation
[NH2:1][C:2]1[N:11]=[CH:10][C:9]2[C:8](=[O:12])[CH2:7][CH:6]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3Br)[CH2:5][C:4]=2[N:3]=1.NC1N=CC2C(=O)CC([C:32]3[CH:37]=[CH:36][C:35](F)=[CH:34][C:33]=3[C:39]3[CH:40]=[N:41]C=CC=3)CC=2N=1>>[NH2:1][C:2]1[N:11]=[CH:10][C:9]2[C:8](=[O:12])[CH2:7][CH:6]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[C:32]3[CH:37]=[CH:36][CH:35]=[C:34]4[C:33]=3[CH:39]=[CH:40][NH:41]4)[CH2:5][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 58269374HCID 58269374, compoundHCID 58269407HCID 58269407, compound

Product 1

HCID 67159084HCID 67159084, compound

Procedure

The title compound was prepared from 2-amino-7-(2-bromo-phenyl)-7,8-dihydro-6H-quinazolin-5-one (example 2/h stage 2), following the procedure describing the synthesis of 2-amino-7-(4-fluoro-2-pyridin-3-yl-phenyl)-7,8-dihydro-6H-quinazolin-5-one using 4-boronic acid-1H-indole instead of 3-pyridyl boronic acid.

Sources & evidence

ORD record
ord-212dec2b091a4ab6acd8bbf4365d0f19
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

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