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HRID20465

反应详情

EQUATION

反应方程式

HRID 20465 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)OC(=O)N1[C@@H]([C@@H](O)[C@H](Cc2cccc(OC(F)(F)F)c2)[N+](=O)[O-])COC1(C)C
HCID68560688

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1[C@@H]([C@@H](O)[C@@H](N)Cc2cccc(OC(F)(F)F)c2)COC1(C)C
HCID68561572

未命名化合物

收率 92.4%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Zn]
催化剂HCID23994

Zinc

Zn

结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

Add zinc (8.46 g, 129.4 mmoles) to (R)-4-[(1R,2S)-1-Hydroxy-2-nitro-3-(3-trifluoromethoxy-phenyl)-propyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester (6.01 g, 12.9 mmoles) in acetic acid (75 mL) and stir at room temperature for 10 minutes. Filter and wash the solids with water. Extract with ethyl acetate. Wash organic layer with 0.1 N sodium hydroxide and saturated aqueous sodium chloride. Dry over sodium sulfate, filter and concentrate to give 5.18 g (92% yield) of the title compound as a white solid.

WORKUP

后处理

  1. filtrationFilter
  2. washwash the solids with water
  3. extractionExtract with ethyl acetate
  4. dry with materialDry over sodium sulfate
  5. filtrationfilter
  6. concentrationconcentrate