(Pyridin-4-yl)boronic acid → 2-Amino-4-methyl-7-(2-pyridin-4-yl-phenyl)-7,8-dihydro-6H-quinazolin-5-one

HRID 2046504Notes

Reaction equation

HRID 2046504 reaction equation
CC1C2C(=O)CCCC=2N=CN=1.[N:13]1[CH:18]=[CH:17][C:16](B(O)O)=[CH:15][CH:14]=1.[NH2:22][C:23]1[N:32]=[C:31]([CH3:33])[C:30]2[C:29](=[O:34])[CH2:28][CH:27]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3C3C=CC=CC=3)[CH2:26][C:25]=2[N:24]=1>>[NH2:22][C:23]1[N:32]=[C:31]([CH3:33])[C:30]2[C:29](=[O:34])[CH2:28][CH:27]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=3[C:16]3[CH:17]=[CH:18][N:13]=[CH:14][CH:15]=3)[CH2:26][C:25]=2[N:24]=1

Participants

4

Reactant 3

HCID 2734379(Pyridin-4-yl)boronic acidHCID 58269344HCID 58269344, compoundHCID 67159366HCID 67159366, compound

Product 1

HCID 582694042-Amino-4-methyl-7-(2-pyridin-4-yl-phenyl)-7,8-dihydro-6H-quinazolin-5-one

Procedure

The title compound was prepared from 2-amino-4-methyl-7-(2-bromo-phenyl), 4-methyl-7,8-dihydro-6H-quinazolin-5-one (example 3/i) and pyridin-4-yl-boronic acid, following the procedure describing the synthesis of 2-amino-7-biphenyl-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one (example 5/a stage 1).

Sources & evidence

ORD record
ord-165da59281c14642ad91bbf6c604df75
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

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