Water → HCID 58269368, compound

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared reacting 5-(2-bromo-4-fluoro-phenyl)-cyclohexane-1,3-dione (example 1/f stage 2) (5 g, 17.4 mmol) and sodium acetate (1.42 g, 17.4 mmol) in neat acetic anhydride (30 ml). The reaction mixture was heated for 2 h at 100° C. and allowed to cool to ambient temperature whereupon water (60 ml) was added. The mixture was extracted with EtOAc (2×80 ml) and the combined organic layers washed with sat aq sodium bicarbonate until the pH was neutral. Then the organics were dried over sodium sulphate, filtered, and the solvent removed in vacuo.

Provenance & Evidence