2-amino-7-(4-fluoro-biphenyl-2-yl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one → HCID 76750937, compound

HRID 2046509Notes

Reaction equation

HRID 2046509 reaction equation
NC1N=C(C)C2C(=O)CC(C3C=C([F:20])C=CC=3C3C=CC=CC=3)CC=2N=1.[NH2:27][C:28]1[N:37]=[C:36]([CH3:38])[C:35]2[C:34](=[N:39][OH:40])[CH2:33][CH:32]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=3[C:47]3[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=3)[CH2:31][C:30]=2[N:29]=1>>[NH2:27][C:28]1[N:37]=[C:36]([CH3:38])[C:35]2[C:34](=[N:39][OH:40])[CH2:33][CH:32]([C:41]3[CH:46]=[CH:45][C:44]([F:20])=[CH:43][C:42]=3[C:47]3[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=3)[CH2:31][C:30]=2[N:29]=1

Participants

3

Reactant 2

HCID 671593852-amino-7-(4-fluoro-biphenyl-2-yl)-4-methyl-7,8-dihydro-6H-quinazolin-5-oneHCID 767508942-amino-7-biphenyl-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

Product 1

HCID 76750937HCID 76750937, compound

Procedure

The title compound was prepared from 2-amino-7-(4-fluoro-biphenyl-2-yl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one (16 mg, 0.046 mmol) from stage 1, following the procedure describing the synthesis of 2-amino-7-biphenyl-2-yl-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime (example 5/a stage 2—method A).

Sources & evidence

ORD record
ord-99eb9710272b4a86b46c015f51a0f2e4
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

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