HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propionic anhydride → 2-Amino-4-ethyl-7-(4-fluoro-phenyl)-7,8-dihydro-6H-quinazolin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propionic anhydride | HCID 31263 | — |
| Reactant | 5-(4-Fluorophenyl)cyclohexane-1,3-dione | HCID 730136 | — |
| Reactant | 2-Amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one | HCID 17221208 | — |
| Product | 2-Amino-4-ethyl-7-(4-fluoro-phenyl)-7,8-dihydro-6H-quinazolin-5-one | HCID 17221209 | — |
Reaction Steps
The title compound was prepared from 5-(4-fluoro-phenyl)-cyclohexane-1,3-dione, following the procedure describing the synthesis of 2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one (example 3/a stage 1, 2 and 3). Propionic anhydride was used instead of acetic anhydride in stage 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592430B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-b750d009c5a744e49a290c35258b8a40 |
| Source note | uspto-grants-2013_11 |