2-Amino-4-ethyl-7-(4-fluoro-phenyl)-7,8-dihydro-6H-quinazolin-5-one → 2-Amino-4-ethyl-7-(4-fluoro-phenyl)-7,8-dihydro-6H-quinazolin-5-one oxime

HRID 2046513Notes

Reaction equation

HRID 2046513 reaction equation
[NH2:1][C:2]1[N:11]=[C:10]([CH2:12][CH3:13])[C:9]2[C:8](=O)[CH2:7][CH:6]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH2:5][C:4]=2[N:3]=1.NC1N=C(C)C2C(=[N:34][OH:35])CC(C3C=CC(F)=CC=3)CC=2N=1>>[NH2:1][C:2]1[N:11]=[C:10]([CH2:12][CH3:13])[C:9]2[C:8](=[N:34][OH:35])[CH2:7][CH:6]([C:15]3[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=3)[CH2:5][C:4]=2[N:3]=1

Participants

3

Reactant 2

HCID 172212092-Amino-4-ethyl-7-(4-fluoro-phenyl)-7,8-dihydro-6H-quinazolin-5-oneHCID 866535532-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime

Product 1

HCID 767509132-Amino-4-ethyl-7-(4-fluoro-phenyl)-7,8-dihydro-6H-quinazolin-5-one oxime

Procedure

The title compound was prepared from 2-amino-4-ethyl-7-(4-fluoro-phenyl)-7,8-dihydro-6H-quinazolin-5-one from stage 3, following the procedure describing the synthesis of 2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one oxime (example 3/a stage 4).

Sources & evidence

ORD record
ord-36a7e679993844b8a40bdfb176e40974
Source dataset
uspto-grants-2013_11
Patent number
US08592430B2

Reaction notes

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