HCID 86702280, compound → HCID 178425473, compound

HRID 2046530Notes

Reaction equation

HRID 2046530 reaction equation
[CH3:1][C:2]1[N:7]2[N:8]=[C:9]([CH2:11][P+](C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[N:10]=[C:6]2[C:5]([CH3:31])=[CH:4][CH:3]=1.[C:32]1([C:38]2[N:39]=[C:40]([CH:43]=O)[NH:41][CH:42]=2)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH3:1][C:2]1[N:7]2[N:8]=[C:9]([CH:11]=[CH:43][C:40]3[NH:41][CH:42]=[C:38]([C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=4)[N:39]=3)[N:10]=[C:6]2[C:5]([CH3:31])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 86702280HCID 86702280, compoundHCID 178519948HCID 178519948, compound

Product 1

HCID 178425473HCID 178425473, compound

Procedure

One example of a synthetic route for the synthesis of the PET-preursor compound of formula IIa is shown in scheme 4: The (5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylmethyl)-triphenylphosphonium salt 1 is coupled under basic conditions with commercially available 4-phenyl-1H-imidazole-2-carbaldehyde 2 (Anichem Inc. catalog number FH10994) to form the 5,8-Dimethyl-2-[2-(4-phenyl-1H-imidazol-2-yl)-vinyl]-[1,2,4]triazolo[1,5-a]pyridine, compound 3.

Sources & evidence

ORD record
ord-ea18443a800e4f659ee792ba8ba7cd2c
Source dataset
uspto-grants-2013_11
Patent number
US08592449B1

Reaction notes

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