HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-Chloromaleic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Gantacurium | HCID 10102486 | — |
| Reactant | Chlorofumarate | HCID 21982578 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Chloromaleic acid | HCID 5284488 | — |
Reaction Steps
Gantacurium, an asymmetrical chlorofumarate, was prepared in four chemical transformations from compound (XIIIB) using minor modifications of previously reported chemistry, see WO2005/041960. Isoquinolylalkanol compound (XIIIB) was condensed with trans-2,3-dichlorosuccinic anhydride and triethylamine in acetonitrile solvent to provide a monoester of chlorofumaric acid, which was then condensed with isoquinolylalkanol compound (XIIIC):
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592451B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-bfa23cbf96724e8aae7a97aca570a95b |
| Source note | uspto-grants-2013_11 |