反应详情

In analogy to the procedure described for the preparation of intermediate A-1 [B] and A-1 [C], (rac)-7-bromo-chroman-4-ylamine has been coupled with 1-(2,2,2-trifluoroacetamido) cyclopropanecarboxylic acid (intermediate A-1 [A]) to give 1-(2,2,2-trifluoro-acetylamino)-cyclopropanecarboxylic acid ((rac)-7-bromo-chroman-4-yl)-amide, which was subsequently reacted with 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) to yield the title compound as light yellow solid. MS: 453.2 (M−H−).