1-(2,2,2-Trifluoroacetamido)cyclopropane-1-carboxylic acid → HCID 89391521, compound

HRID 2046558Notes

Reaction equation

HRID 2046558 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7]([NH2:12])([CH3:11])[CH2:6][CH2:5]2.[F:13][C:14]([F:25])([F:24])[C:15]([NH:17][C:18]1([C:21](O)=[O:22])[CH2:20][CH2:19]1)=[O:16]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7]([NH:12][C:21]([C:18]1([NH:17][C:15](=[O:16])[C:14]([F:13])([F:24])[F:25])[CH2:19][CH2:20]1)=[O:22])([CH3:11])[CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 129888001-(2,2,2-Trifluoroacetamido)cyclopropane-1-carboxylic acidHCID 682967755-Bromo-1-methyl-1-indanamine

Product 1

HCID 89391521HCID 89391521, compound

Procedure

In analogy to the procedure described for the preparation of intermediate A-1 [B], (rac)-5-bromo-1-methyl-indan-1-ylamine has been coupled with 1-(2,2,2-trifluoroacetamido)cyclopropanecarboxylic acid (intermediate A-1 [A]) to yield the title compound as light brown solid. MS: 402.9 (M−H−, 1Br).

Sources & evidence

ORD record
ord-77aaec28eef441d58ace1c34f69d24cd
Source dataset
uspto-grants-2013_11
Patent number
US08592426B2

Reaction notes

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