HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid → (1-{(S)-5-[5-Chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-indan-1-ylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid | HCID 688396 | — |
| Reactant | (S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-indan-1-ylamine | HCID 68296736 | — |
| Product | (1-{(S)-5-[5-Chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-indan-1-ylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester | HCID 60142568 | — |
Reaction Steps
In analogy to the procedures described for the preparation of intermediate A-1 [B], (S)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-indan-1-ylamine (intermediate A-11) was coupled with 1-tert-butoxycarbonylamino-cyclopropanecarboxylic acid to yield the title compound as light yellow amorphous solid. MS: 527.2 (MH+, 1Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592426B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-f1908105ca78446686bad2acececc35b |
| Source note | uspto-grants-2013_11 |