HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridazine-4-carboxylic Acid → Pyridazine-4-carboxylic acid (1-{(rac)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-7-fluoro-indan-1-ylcarbamoyl}-cyclopropyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridazine-4-carboxylic Acid | HCID 2761046 | — |
| Reactant | 1-Amino-cyclopropanecarboxylic acid {(rac)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-7-fluoro-indan-1-yl}-amide | HCID 60142833 | — |
| Product | Pyridazine-4-carboxylic acid (1-{(rac)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-7-fluoro-indan-1-ylcarbamoyl}-cyclopropyl)-amide | HCID 60142835 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate A-1 [B], 1-amino-cyclopropanecarboxylic acid{(rac)-5-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-7-fluoro-indan-1-yl}-amide (example 32) has been coupled with pyridazine-4-carboxylic acid to yield the title compound as light yellow solid. MS: 551.1 (MH+, 1Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592426B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-58b68db8af4f461b91656c83f7906640 |
| Source note | uspto-grants-2013_11 |