HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridazine-4-carboxylic Acid → Pyridazine-4-carboxylic acid (1-{(rac)-6-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-2,3-dihydro-benzofuran-3-ylcarbamoyl}-cyclopropyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridazine-4-carboxylic Acid | HCID 2761046 | — |
| Reactant | 1-Amino-cyclopropanecarboxylic acid {(rac)-6-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-2,3-dihydro-benzofuran-3-yl}-amide | HCID 60143098 | — |
| Product | Pyridazine-4-carboxylic acid (1-{(rac)-6-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-2,3-dihydro-benzofuran-3-ylcarbamoyl}-cyclopropyl)-amide | HCID 60143099 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate A-1 [B], 1-amino-cyclopropanecarboxylic acid{(rac)-6-[5-chloro-3-fluoro-2-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenyl]-2,3-dihydro-benzofuran-3-yl}-amide (example 45) has been coupled with pyridazine-4-carboxylic acid to yield the title compound as yellow solid. MS: 535.1 (MH+, 1Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592426B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-76b2e85f3ec14d76b05bc5f8d5fc42ac |
| Source note | uspto-grants-2013_11 |