HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 60141326, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (1-{(rac)-6-[5-Chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)-phenyl]-2,3-dihydro-benzo[b]thiophen-3-ylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester | HCID 60141325 | — |
| Product | HCID 60141326 | HCID 60141326 | — |
Reaction Steps
In analogy to the procedure described for the preparation of intermediate A-11 [C], (1-{(rac)-6-[5-chloro-3-fluoro-2-(2-methyl-2H-tetrazol-5-yl)-phenyl]-2,3-dihydro-benzo[b]thiophen-3-ylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester (example 60) has been treated with trifluoroacetic acid (90%) to give the title compound as light yellow amorphous solid. MS: 445.1 (MH+, 1Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592426B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-620ff5ffa7e048de86ea83ae76cf08c7 |
| Source note | uspto-grants-2013_11 |