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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2046626Generated: October 26, 2026

2-Chloro-4-fluorobenzonitrile → 2-chloro-4-[(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidin-1-yl]benzonitrile

https://huagongshe.com/reaction/2046626

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-4-fluorobenzonitrileHCID 109000—
Reactant(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidineHCID 55299039—
Product2-chloro-4-[(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidin-1-yl]benzonitrileHCID 16066091—

Reaction Steps

Using compound 1 and 2-chloro-4-fluorobenzonitrile as starting materials, the title compound was obtained by the same manner as shown in Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08592452B2
Source datasetuspto-grants-2013_11
ORD IDord-ae3a0cba4d1341f7bf79353a91535636
Source noteuspto-grants-2013_11