4-Fluoro-3-methylbenzonitrile → HCID 59370521, compound

HRID 2046627Notes

Reaction equation

HRID 2046627 reaction equation
[OH:1][C:2]([C@H:5]1[CH2:9][CH2:8][NH:7][C@H:6]1[CH3:10])([CH3:4])[CH3:3].F[C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][C:13]=1[CH3:20]>>[OH:1][C:2]([C@H:5]1[CH2:9][CH2:8][N:7]([C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][C:13]=2[CH3:20])[C@H:6]1[CH3:10])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 27791804-Fluoro-3-methylbenzonitrileHCID 55299039(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine

Product 1

HCID 59370521HCID 59370521, compound

Procedure

Using compound 1 and 4-fluoro-3-methylbenzonitrile as starting materials, the title compound was obtained by the same manner as shown in Example 1 (reaction temperature 90° C., reaction time 3 hr).

Sources & evidence

ORD record
ord-8c87a1a04d174e37b83437e24edf724a
Source dataset
uspto-grants-2013_11
Patent number
US08592452B2

Reaction notes

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