反应详情

Using 2-chloro-4-fluoro-3-ethylbenzonitrile (1.10 g), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (1.24 g) and lithium carbonate (930 mg), the title compound was obtained as a colorless solid (yield: 255 mg) by an operation similar to that in Example 3.