Lithium Carbonate → HCID 59370525, compound

HRID 2046669Notes

Reaction equation

HRID 2046669 reaction equation
[F:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[OH:11][C:12]([C@H:15]1[CH2:19][CH2:18][NH:17][C@H:16]1[CH3:20])([CH3:14])[CH3:13].C(=O)([O-])[O-].[Li+].[Li+]>>[F:1][C:2]1[CH:9]=[C:8]([N:17]2[CH2:18][CH2:19][C@H:15]([C:12]([OH:11])([CH3:14])[CH3:13])[C@@H:16]2[CH3:20])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 775452,4-DifluorobenzonitrileHCID 55299039(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine

Product 1

HCID 59370525HCID 59370525, compound

Procedure

Using 2,4-difluorobenzonitrile (696 mg), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (1.04 g) and lithium carbonate (784 mg), the title compound was obtained as a colorless solid (yield: 838 mg) by an operation similar to that in Example 3.

Sources & evidence

ORD record
ord-e7cae8390ced4b368cac7275bfb9e336
Source dataset
uspto-grants-2013_11
Patent number
US08592452B2

Reaction notes

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