Lithium Carbonate → HCID 59370494, compound

HRID 2046671Notes

Reaction equation

HRID 2046671 reaction equation
[F:1][C:2]1[C:9]([F:10])=[C:8](F)[C:7]([F:12])=[CH:6][C:3]=1[C:4]#[N:5].[OH:13][C:14]([C@H:17]1[CH2:21][CH2:20][NH:19][C@H:18]1[CH3:22])([CH3:16])[CH3:15].C(=O)([O-])[O-].[Li+].[Li+]>>[F:1][C:2]1[C:9]([F:10])=[C:8]([N:19]2[CH2:20][CH2:21][C@H:17]([C:14]([OH:13])([CH3:16])[CH3:15])[C@@H:18]2[CH3:22])[C:7]([F:12])=[CH:6][C:3]=1[C:4]#[N:5]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 6002242,3,4,5-TetrafluorobenzonitrileHCID 55299039(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine

Product 1

HCID 59370494HCID 59370494, compound

Procedure

Using 2,3,4,5-tetrafluorobenzonitrile (876 mg), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (1.04 g) and lithium carbonate (784 mg), the title compound was obtained as a colorless solid (yield: 922 mg) by an operation similar to that in Example 3.

Sources & evidence

ORD record
ord-0831efdc723145afad58eb52d4b6d42a
Source dataset
uspto-grants-2013_11
Patent number
US08592452B2

Reaction notes

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