Lithium Carbonate → HCID 59370510, compound

HRID 2046672Notes

Reaction equation

[F:1][C:2]1[C:9](F)=[C:8]([F:11])[C:7]([F:12])=[C:4]([C:5]#[N:6])[C:3]=1[C:13]#[N:14].[OH:15][C:16]([C@H:19]1[CH2:23][CH2:22][NH:21][C@H:20]1[CH3:24])([CH3:18])[CH3:17].C(=O)([O-])[O-].[Li+].[Li+]>>[F:12][C:7]1[C:8]([F:11])=[C:9]([N:21]2[CH2:22][CH2:23][C@H:19]([C:16]([OH:15])([CH3:18])[CH3:17])[C@@H:20]2[CH3:24])[C:2]([F:1])=[C:3]([C:13]#[N:14])[C:4]=1[C:5]#[N:6]

Participants

Reactant 3

HCID 11125Lithium Carbonate

HCID 74600Tetrafluorophthalonitrile

HCID 55299039(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine

Product 1

HCID 59370510HCID 59370510, compound

Procedure

Using 3,4,5,6-tetrafluorophthalonitrile (464 mg), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (480 mg) and lithium carbonate (362 mg), the title compound was obtained as a pale-yellow solid (yield: 250 mg) by an operation similar to that in Example 3.

Sources & evidence

ORD record: ord-f0b26080140c493bb523117a79e82de9
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592452B2

Reaction notes

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