HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium Carbonate → 2,3-dichloro-4-[(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidin-1-yl]-5-methylbenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine | HCID 55299039 | — |
| Reactant | 2,3-Dichloro-4-fluoro-5-methylbenzonitrile | HCID 59370549 | — |
| Product | 2,3-dichloro-4-[(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidin-1-yl]-5-methylbenzonitrile | HCID 59370526 | — |
Reaction Steps
Using 2,3-dichloro-4-fluoro-5-methylbenzonitrile (1.02 g), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (1.04 g) and lithium carbonate (776 mg), the title compound was obtained as a colorless solid (yield: 68 mg) by an operation similar to that in Example 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592452B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-dcb5ddb7ee1e444db05cdd98d3cfdb3d |
| Source note | uspto-grants-2013_11 |