Lithium Carbonate → HCID 16066092, compound

HRID 2046675Notes

Reaction equation

HRID 2046675 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([O:10][CH3:11])[CH:3]=1.[OH:12][C:13]([C@H:16]1[CH2:20][CH2:19][NH:18][C@H:17]1[CH3:21])([CH3:15])[CH3:14].C(=O)([O-])[O-].[Li+].[Li+]>>[OH:12][C:13]([C@H:16]1[CH2:20][CH2:19][N:18]([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([O:10][CH3:11])[CH:3]=2)[C@H:17]1[CH3:21])([CH3:15])[CH3:14]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 27833294-Fluoro-2-methoxybenzonitrileHCID 55299039(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine

Product 1

HCID 16066092HCID 16066092, compound

Procedure

Using 4-fluoro-2-methoxybenzonitrile (352 mg), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (470 mg) and lithium carbonate (188 mg), the title compound was obtained as an orange solid (yield: 195 mg) by an operation similar to that in Example 3.

Sources & evidence

ORD record
ord-8418ae6966f24d1384a51be87cb6e674
Source dataset
uspto-grants-2013_11
Patent number
US08592452B2

Reaction notes

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