Lithium Carbonate → HCID 59370513, compound

HRID 2046677Notes

Reaction equation

HRID 2046677 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[O:10][CH3:11].[OH:12][C:13]([C@H:16]1[CH2:20][CH2:19][NH:18][C@H:17]1[CH3:21])([CH3:15])[CH3:14].C(=O)([O-])[O-].[Li+].[Li+]>>[OH:12][C:13]([C@H:16]1[CH2:20][CH2:19][N:18]([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=2[O:10][CH3:11])[C@H:17]1[CH3:21])([CH3:15])[CH3:14]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 27373654-Fluoro-3-methoxybenzonitrileHCID 55299039(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine

Product 1

HCID 59370513HCID 59370513, compound

Procedure

Using 4-fluoro-3-methoxybenzonitrile (232 mg), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (390 mg) and lithium carbonate (153 mg), the title compound was obtained as a white solid (yield: 42 mg) by an operation similar to that in Example 3.

Sources & evidence

ORD record
ord-0fc04d9a7aee4ef5a332841cfb7c5d32
Source dataset
uspto-grants-2013_11
Patent number
US08592452B2

Reaction notes

Loading…