Lithium Carbonate → HCID 59370546, compound

HRID 2046678Notes

Reaction equation

HRID 2046678 reaction equation
F[C:2]1[CH:3]=[C:4]([C:10]#[N:11])[C:5](=[CH:8][CH:9]=1)[C:6]#[N:7].[OH:12][C:13]([C@H:16]1[CH2:20][CH2:19][NH:18][C@H:17]1[CH3:21])([CH3:15])[CH3:14].C(=O)([O-])[O-].[Li+].[Li+]>>[OH:12][C:13]([C@H:16]1[CH2:20][CH2:19][N:18]([C:2]2[CH:3]=[C:4]([C:10]#[N:11])[C:5](=[CH:8][CH:9]=2)[C:6]#[N:7])[C@H:17]1[CH3:21])([CH3:15])[CH3:14]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 1034231,2-Benzenedicarbonitrile, 4-fluoro-HCID 55299039(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine

Product 1

HCID 59370546HCID 59370546, compound

Procedure

Using 4-fluorophthalonitrile (500 mg), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (870 mg) and lithium carbonate (341 mg), the title compound was obtained as a yellow solid (yield: 42 mg) by an operation similar to that in Example 3.

Sources & evidence

ORD record
ord-ffb22429b3934ef09244670c89a52c4c
Source dataset
uspto-grants-2013_11
Patent number
US08592452B2

Reaction notes

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