Lithium Carbonate → HCID 59370503, compound

HRID 2046688Notes

Reaction equation

HRID 2046688 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[OH:14][C:15]([C@H:18]1[CH2:22][CH2:21][NH:20][C@H:19]1[CH3:23])([CH3:17])[CH3:16].C(=O)([O-])[O-].[Li+].[Li+]>>[OH:14][C:15]([C@H:18]1[CH2:22][CH2:21][N:20]([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=2[C:10]([F:13])([F:12])[F:11])[C@H:19]1[CH3:23])([CH3:17])[CH3:16]

Participants

4

Reactant 3

HCID 11125Lithium CarbonateHCID 1442554-Fluoro-3-(trifluoromethyl)benzonitrileHCID 55299039(2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine

Product 1

HCID 59370503HCID 59370503, compound

Procedure

Using 4-fluoro-3-(trifluoromethyl)benzonitrile (300 mg), (2S,3S)-3-(1-hydroxy-1-methylethyl)-2-methylpyrrolidine 1/2 oxalate (359 mg) and lithium carbonate (140 mg), the title compound was obtained as a colorless solid (yield: 180 mg) by an operation similar to that in Example 3.

Sources & evidence

ORD record
ord-952359f9166c44329a85bb9386f74e82
Source dataset
uspto-grants-2013_11
Patent number
US08592452B2

Reaction notes

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