HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1'-Benzyl-6-bromo-4-hydroxy-spiro[chromane-2,4'-piperidine]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1'-Benzyl-6-bromospiro[chroman-2,4'-piperidin]-4-one | HCID 12887955 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1'-Benzyl-6-bromo-4-hydroxy-spiro[chromane-2,4'-piperidine] | HCID 52952196 | 99.1% |
Reaction Steps
A mixture of 1′-benzyl-6-bromo-spiro[chromane-2,4′-piperidine]-4-one (3.0 g, 7.8 mmol) and NaBH4 (1.47 g, 38.75 mmol) in MeOH (20 ml) was stirred at RT. After 3 h, the solution was poured into water and the product was extracted with DCM (50 ml). The organic phase was dried over Na2SO4, filtered and evaporated under vacuum to give 1′-benzyl-6-bromo-4-hydroxy-spiro[chromane-2,4′-piperidine] (3.0 g) as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592444B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-d234f0477d2d4badb21ecf39c75919eb |
| Source note | uspto-grants-2013_11 |