HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Acrylate → (E)-3-{1'-Phenyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Acrylate | HCID 7294 | — |
| Reactant | (E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 52952087 | — |
| Reactant | 1'-Phenyl-6-bromo-spiro[chromane-2,4'-piperidine]-4-one | HCID 66932220 | — |
| Product | (E)-3-{1'-Phenyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 66932530 | — |
Reaction Steps
(E)-3-{1′-Phenyl-4-oxo-spiro[chromane-2,4′-piperidine]-6-yl}-acrylic acid methyl ester was synthesized starting from 1′-phenyl-6-bromo-spiro[chromane-2,4′-piperidine]-4-one (650 mg, 1.75 mmol) and methyl acrylate (541 mg, 6.2 mmol) according to the procedure described for Intermediate 1, Step B, giving 541 mg of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592444B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-6a2e646b0bac49e7bac0f19a026d8258 |
| Source note | uspto-grants-2013_11 |