HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Bromoethyl)-4-chlorobenzene → HCID 66932159, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Bromoethyl)-4-chlorobenzene | HCID 23029 | — |
| Reactant | (E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 52952087 | — |
| Product | HCID 66932159 | HCID 66932159 | 92.7% |
Reaction Steps
(E)-3-{4-Oxo-spiro[chromane-2,4′-piperidine]-6-yl}-acrylic acid methyl ester (169 mg, 0.500 mmol, Intermediate 1, hydrochloride salt) was alkylated using 1-(2-bromo-ethyl)-4-chloro-benzene (0.15 ml, 1.5 mmol) as described in Example 56, Step A, giving (E)-3-{1′-[2-(4-chloro-phenyl)-ethyl]-4-oxo-spiro[chromane-2,4′-piperidine]-6-yl}-acrylic acid methyl ester (204 mg) as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592444B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-1e400f05881449eca2788f9be2918ac2 |
| Source note | uspto-grants-2013_11 |