HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorophenethyl bromide → HCID 66932564, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorophenethyl bromide | HCID 2756964 | — |
| Reactant | (E)-3-{1'-tert-butoxycarbonyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl}-acrylic acid methyl ester | HCID 52952087 | — |
| Product | HCID 66932564 | HCID 66932564 | 85.5% |
Reaction Steps
(E)-3-{4-Oxo-spiro[chromane-2,4′-piperidine]-6-yl}-acrylic acid methyl ester (169 mg, 0.500 mmol, Intermediate 1, hydrochloride salt) was alkylated using 1-(2-bromo-ethyl)-2-fluoro-benzene (0.16 ml, 1.5 mmol) as described in Example 56, Step A, giving (E)-3-{1′-[2-(2-fluoro-phenyl)-ethyl]-4-oxo-spiro[chromane-2,4′-piperidine]-6-yl}-acrylic acid methyl ester (181 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592444B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-d3b48b54618245d480dfd3a10ce70c10 |
| Source note | uspto-grants-2013_11 |