HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Fluoro-5-propoxyphenyl)boronic acid → 3-Amino-6-(2-fluoro-5-propoxyphenyl)picolinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Fluoro-5-propoxyphenyl)boronic acid | HCID 16217464 | — |
| Reactant | 3-Amino-6-bromopicolinic acid | HCID 45480452 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | 3-Amino-6-(2-fluoro-5-propoxyphenyl)picolinic acid | HCID 59226591 | 75% |
Reaction Steps
Method 1 was followed using 3-amino-6-bromopicolinic acid (1.0 equiv.) and 2-fluoro-5-propoxyphenylboronic acid (1.5 equiv.) and Pd(dppf)Cl2-DCM (0.05 equiv.) to give 3-amino-6-(2-fluoro-5-propoxyphenyl)picolinic acid in 75% yield. LC/MS=291.0 (M+H), Rt=0.81 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592455B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-db72e48b60b2452b9ba96be0f35352b1 |
| Source note | uspto-grants-2013_11 |