(2-Fluoro-5-propoxyphenyl)boronic acid → HCID 59226511, compound

HRID 2046838Notes

Reaction equation

HRID 2046838 reaction equation
[NH2:1][C:2]1[C:3]([C:10]([OH:12])=[O:11])=[N:4][C:5](Br)=[C:6]([F:8])[CH:7]=1.[F:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][CH3:23])=[CH:16][C:15]=1B(O)O>>[NH2:1][C:2]1[C:3]([C:10]([OH:12])=[O:11])=[N:4][C:5]([C:19]2[CH:18]=[C:17]([O:20][CH2:21][CH2:22][CH3:23])[CH:16]=[CH:15][C:14]=2[F:13])=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 16217464(2-Fluoro-5-propoxyphenyl)boronic acidHCID 726988793-Amino-6-bromo-5-fluoropicolinic acid

Product 1

HCID 59226511HCID 59226511, compoundYield 28%

Procedure

Method 1 was followed using 3-amino-6-bromo-5-fluoropicolinic acid (1.0 equiv.) and 2-fluoro-5-propoxyphenylboronic acid (1.3 equiv.) and Pd(dppf)C12-DCM (0.05 equiv.) to give 3-amino-5-fluoro-6-(2-fluoro-5-propoxyphenyl)picolinic acid in 28% yield. LC/MS=309.1 (M+H), Rt=1.00 min.

Sources & evidence

ORD record
ord-7101771560f84f7389877c60658740f0
Source dataset
uspto-grants-2013_11
Patent number
US08592455B2

Reaction notes

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