HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2,5-Difluorophenyl)boronic acid → HCID 59226541, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2,5-Difluorophenyl)boronic acid | HCID 2734335 | — |
| Reactant | 6-Bromo-5-fluoropicolinic Acid | HCID 53401194 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | HCID 59226541 | HCID 59226541 | 80% |
Reaction Steps
Method 1 was followed using 6-bromo-5-fluoropicolinic acid (1.0 equiv.) and 2,5-difluorophenylboronic acid (1.3 equiv.) and Pd(dppf)Cl2-DCM (0.05 equiv.) to give 6-(2,5-difluorophenyl)-5-fluoropicolinic acid in 80% yield. LC/MS=254.1 (M+H), Rt=0.74 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592455B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-910a5e97008b47f1929d7698acdc631c |
| Source note | uspto-grants-2013_11 |