HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-5-methoxyphenylboronic acid → 3-Fluoro-6-(2-fluoro-5-methoxyphenyl)picolinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-5-methoxyphenylboronic acid | HCID 4157211 | — |
| Reactant | 6-Bromo-3-fluoropyridine-2-carboxylic acid | HCID 70700873 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | 3-Fluoro-6-(2-fluoro-5-methoxyphenyl)picolinic acid | HCID 59226557 | 89% |
Reaction Steps
Method 1 was followed using 6-bromo-3-fluoropicolinic acid (1.0 equiv.) and 2-fluoro-5-methoxyphenylboronic acid (1.3 equiv.) and Pd(dppf)Cl2-DCM (0.15 equiv.) to give 3-fluoro-6-(2-fluoro-5-methoxyphenyl)picolinic acid in 89% yield. LC/MS=266.1 (M+H), Rt=0.79 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592455B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-7c0ffc2f9d0e482e9454ab583b28f188 |
| Source note | uspto-grants-2013_11 |