Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Fluoro-5-methoxyphenylboronic acid → 5-Fluoro-6-(2-fluoro-5-methoxyphenyl)picolinic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Fluoro-5-methoxyphenylboronic acid | HCID 4157211 | — |
| 반응물 | 6-Bromo-5-fluoropicolinic Acid | HCID 53401194 | — |
| 촉매 | HCID 178418807 | HCID 178418807 | — |
| 생성물 | 5-Fluoro-6-(2-fluoro-5-methoxyphenyl)picolinic acid | HCID 59226605 | 86% |
반응 단계
Method 1 was followed using 6-bromo-5-fluoropicolinic acid (1.0 equiv.) and 2-fluoro-5-methoxyphenylboronic acid (1.3 equiv.) and Pd(dppf)Cl2-DCM (0.15 equiv.) to give 5-fluoro-6-(2-fluoro-5-methoxyphenyl)picolinic acid in 86% yield. LC/MS=266.1 (M+H), Rt=0.79 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08592455B2 |
| 출처 데이터셋 | uspto-grants-2013_11 |
| ORD ID | ord-45d9b6f543cf482b8ba96263f6666e3c |
| 출처 메모 | uspto-grants-2013_11 |