HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Benzyloxy-2-fluorophenylboronic acid → 6-(4-(Benzyloxy)-2-fluorophenyl)-3-fluoropicolinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Benzyloxy-2-fluorophenylboronic acid | HCID 2737786 | — |
| Reactant | 6-Bromo-3-fluoropyridine-2-carboxylic acid | HCID 70700873 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Product | 6-(4-(Benzyloxy)-2-fluorophenyl)-3-fluoropicolinic acid | HCID 59226516 | 41% |
Reaction Steps
Method 1 was followed using 6-bromo-3-fluoropicolinic acid (1.0 equiv.) and 4-(benzyloxy)-2-fluorophenylboronic acid (1.3 equiv.) and Pd(dppf)Cl2-DCM (0.15 equiv.) to give 6-(4-(benzyloxy)-2-fluorophenyl)-3-fluoropicolinic acid in 41% yield. LC/MS=342.1 (M+H), Rt=1.06 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592455B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-3a6c28bd30e040a0a8381c4ced57a99b |
| Source note | uspto-grants-2013_11 |