HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2046873Generated: November 1, 2026
Water → 5-Fluoro-6-(2,3,5-trifluorophenyl)picolinic acid
https://huagongshe.com/reaction/2046873
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Permanganate | HCID 516875 | — |
| Reactant | 3-Fluoro-6-methyl-2-(2,3,5-trifluorophenyl)pyridine | HCID 59226524 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | 5-Fluoro-6-(2,3,5-trifluorophenyl)picolinic acid | HCID 59226491 | 89% |
Reaction Steps
To a solution of 3-fluoro-6-methyl-2-(2,3,5-trifluorophenyl)pyridine (1.0 equiv.) in water and t-BuOH (2:1, 0.06 M) was added potassium permanganate (10 equiv.) and the solution was heated at 90° C. for 5 hours. Upon cooling to room temperature, the solution was filtered, and the filtrate was concentrated under reduced pressure to yield 5-fluoro-6-(2,3,5-trifluorophenyl)picolinic acid in 89% yield. LC/MS=272.0 (M+H), Rt=0.80 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08592455B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-563ad27c1a1f468aa4fc66f317dec206 |
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| Source note | uspto-grants-2013_11 |
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