HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Benzyloxy)-2,6-difluorobenzeneboronic acid → Methyl 6-(3-(benzyloxy)-2,6-difluorophenyl)picolinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Benzyloxy)-2,6-difluorobenzeneboronic acid | HCID 16217704 | — |
| Reactant | Methyl 6-bromopyridine-2-carboxylate | HCID 16217886 | — |
| Product | Methyl 6-(3-(benzyloxy)-2,6-difluorophenyl)picolinate | HCID 59226396 | 95% |
Reaction Steps
Method 6 was followed using methyl 6-bromopicolinate (1.0 equiv.) and 3-(benzyloxy)-2,6-difluorophenylboronic acid (2.5 equiv.) to give methyl 6-(3-(benzyloxy)-2,6-difluorophenyl)picolinate as a light yellow solid in 95% yield. LC/MS=356.2 (M+H), Rt=1.03 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08592455B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-cc513809424b46be86422f2bd30edd4c |
| Source note | uspto-grants-2013_11 |