Methanol → HCID 58431437, compound

Participants

Reaction Steps

The procedure described above for the (S) enantiomer was followed, starting with ((S)-1-{5-Bromo-3-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethyl]pyrrolo[2,3-b]pyridine-1-carbonyl}-3-methylbutyl)-carbamic acid 9H-fluoren-9-ylmethyl ester. 1H NMR and LCMS data match with the data for the racemic compound. Optical rotation: [α]25D=+ 115.7° (c=1.0, MeOH); [α]25D=+ 151.7° (c=1.0, CH2Cl2). HPLC (Chiralcel OD-RH, solvent 60:40 acetonitrile/water isocratic, flow rate 0.5 mL/min, column temperature 30° C., UV detection at 220 nm): tR=32.1 min.

Provenance & Evidence